Boxers face the highest cancer mortality rate of any dog breed, with nearly half of all deaths attributed to cancer. Understanding this genetic predisposition is crucial for early detection and proactive care.
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Did the surgery get it all? How to use the rapid clearance of cfDNA to check for residual disease 14 days after tumor removal.
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A troubling shift has occurred in the lifespan of one of America's most beloved dog breeds. Recent research has uncovered the complex factors behind this decline and potential paths toward improvement.
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Immune-Mediated Hemolytic Anemia is a thrombotic disease. We explain how 'DNA webs' (NETs) released by neutrophils fuel the fire and trigger clots.
Read moreFrom hit-by-cars to GDVs, necrosis releases massive amounts of DNA. How cfDNA correlates with the 'Injury Severity Score' and helps triage the multi-trauma patient.
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Putting a blood tube in a styrofoam box with an ice pack is not 'preservation.' It is a recipe for lysis. We explain the thermodynamics of shipping failure.
Read moreInflammation looks a lot like infection on a blood panel. We explore why cfDNA rises in both, and how it helps quantify the 'cytokine storm'.
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A negative test doesn't guarantee health, and a positive test doesn't always mean cancer. We debunk the binary thinking that leads to clinical errors.
Read moreIn the Emergency Room, we aren't looking for mutations. We are looking for the total burden of cell death. How to use cfDNA to quantify exactly how hard the patient has been hit.
Read moreIt hurts to throw away a sample, but running a compromised test is worse. A checklist of 4 deal-breakers that mean you must redraw.
Read moreWe can find cancer in the blood, but can we tell you where it is? We explore the current limits of localization and the future promise of methylation panels.
Read moreFat in the blood doesn't just look bad; it scatters light and clogs filters. How lipemia distorts cfDNA values and how to handle the 'milky' sample.
Read moreIce crystals are sharp. We explain why refreezing a plasma sample shears long DNA fragments and ruins 'integrity index' diagnostics.
Read moreWhy do samples degrade after 4 hours? It's not just 'aging'—it's a biological cascade of glucose depletion and white blood cell suicide.
Read moreDNA doesn't float naked in the blood—it is wrapped around histone spools called nucleosomes. We explain why measuring the 'spool' might sometimes be better than measuring the 'thread'.
Read moreWhy pink plasma leads to false negatives, and how to define rejection criteria for hemolyzed samples.
Read moreWhy 'high DNA' doesn't always mean cancer, and how sensitive assays separate the tumor signal (ctDNA) from the background noise (cfDNA).
Read moreFrom dry ice disasters to room-temperature rules: a guide to the physics of sample stability during transit.
Read moreUsing serum for cfDNA testing is the most common rookie mistake. We explain why the clotting process creates a 'genomic explosion' that invalidates results.
Read moreStandard clinic centrifuge protocols leave platelets and debris behind. Learn why the 'Double-Spin' is the mandatory standard for liquid biopsy.
Read moreNot all DNA in the blood is the same. We break down the three biological mechanisms that release DNA—programmed death, traumatic injury, and immune defense—and what they tell us about a patient's disease.
Read moreIt’s not just how much DNA is in the blood, but how long the pieces are. Learn how 'fragmentomics' allows us to spot cancer even when total DNA levels are normal.
Read moreWhy does a $0.50 tube ruin a $300 test? We break down the chemistry of EDTA vs. Streck tubes and help you decide which one your clinic needs.
Read moreUnlike antibodies that linger for months, cfDNA is a 'real-time' biomarker that clears in minutes. Here is how to use that speed for post-surgical monitoring and trauma triage.
Read moreHow much cfDNA is too much? We review the data on healthy baselines, the impact of age and breed, and why '0.0' is not the goal.
Read moreA missed 10-minute window or a single freeze-thaw cycle can ruin a liquid biopsy. Here is the strict Standard Operating Procedure (SOP) every clinic needs.
Read moreA deep dive into the origins of cell-free DNA—apoptosis, necrosis, and NETosis—and why this 'real-time' biomarker is revolutionizing veterinary diagnostics.
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